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Eur J Immunol. 2019 Nov 23. doi: 10.1002/eji.201848051. [Epub ahead of print]

Chronic myeloid leukemia-derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells.

Author information

1
Laboratory of Cytometry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
2
Department of Immunology, Faculty of Biology, University of Warsaw, Poland.

Abstract

Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansion of leukemic cells outside the bone marrow, leading to blast crisis.

KEYWORDS:

Foxp3; chronic myeloid leukemia; extracellular vesicles; immunosuppression; regulatory T cells

PMID:
31758697
DOI:
10.1002/eji.201848051

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