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Immunity. 2019 Nov 19;51(5):783-785. doi: 10.1016/j.immuni.2019.10.012.

T Cell Metabolism in a State of Flux.

Author information

1
NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA.
2
NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address: skaech@salk.edu.

Abstract

Our knowledge of T cell metabolism relies primarily on studies performed in vitro that may not fully recapitulate physiological conditions in vivo. In this issue of Immunity, Ma et al. find that the in vivo environment dictates the metabolic phenotype of effector CD8+ T cells-particularly their glucose utilization.

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