Format

Send to

Choose Destination
J Eur Acad Dermatol Venereol. 2019 Nov 16. doi: 10.1111/jdv.16090. [Epub ahead of print]

Recurrent Eczema Herpeticum - A Retrospective European Multicenter Study Evaluating the Clinical Characteristics of Eczema Herpeticum Cases in Atopic Dermatitis Patients.

Author information

1
Dept. of Dermatology and Allergy, Ludwig-Maximilian-University, Munich, Germany.
2
Dept. of Dermatology and Allergy, Charité Universitätsmedizin Berlin, Berlin, Germany.
3
Dept. of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
4
Dept. of Dermatology and Venerology, Skane University Hospital, Malmö, Sweden.
5
Dept. of Dermatology and Allergy, University Clinic of Bonn, Bonn, Germany.
6
Dept. of Dermatology and Allergy, University of Berne, Berne, Switzerland.
7
Dept. of Dermatology and Allergy, Technical University of Munich, Munich, Germany.
8
Dept. of Dermatology and Allergy, University of Hamburg, Hamburg, Germany.

Abstract

BACKGROUND:

Eczema herpeticum (EH) is a disseminated viral infection of eczematous skin disease with the herpes simplex virus. Knowledge on clinical characteristics, risk factors and recurrent disease is limited. Our aim was to better define clinical characteristics and risk factors for EH and especially for recurrent EH.

METHODS:

A retrospective analysis of EH cases assessed the history, clinical signs, prior treatment and laboratory results using a predefined questionnaire.

RESULTS:

A total of 224 EH cases from 8 European centers were included. Extrinsic AD was identified as risk factor for EH, only one patient suffered from intrinsic AD. Early-onset of AD was identified as risk factor for recurrent EH. Pre-treatment with topical steroids, systemic steroids, topical calcineurin inhibitors or plain emollients reflected standard therapy. Many patients showed AD lesions without EH, but skin without AD lesions was never affected by herpetic lesions.

CONCLUSION:

Patients with clinically active, extrinsic AD are at risk for EH. Recurrent EH is associated with confounders of severe atopic distortion, and requires active AD lesions for clinical manifestation. Recurrent eczema herpeticum mainly affects patients with early onset of AD.

KEYWORDS:

Eczema herpeticum; atopic dermatitis; distribution; extrinsic; recurrence

PMID:
31733162
DOI:
10.1111/jdv.16090

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center