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Dev Cell. 2019 Oct 21;51(2):131-132. doi: 10.1016/j.devcel.2019.09.021.

TADs for Life: Chromatin Domain Organization Regulates Lifespan in C. elegans.

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The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037-1002, USA. Electronic address:


In this issue of Developmental Cell, Anderson et al. (2019) show that chromatin domain structure on the X chromosome in C. elegans is dispensable for dosage compensation but regulates longevity and thermotolerance. This study sheds light on the mechanisms of domain formation in C. elegans and how these features affect physiology.

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