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J Perinatol. 2019 Oct 15. doi: 10.1038/s41372-019-0510-y. [Epub ahead of print]

A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors-implications for research on perinatal outcomes in the ECHO program.

Author information

1
University of California San Francisco, San Francisco, CA, USA. amy.padula@ucsf.edu.
2
Columbia University Medical Center, New York, NY, USA.
3
Emory University, Atlanta, GA, USA.
4
North Shore University Health System, Evanston, IL, USA.
5
Rutgers School of Public Health, Piscataway, NJ, USA.
6
Oregon Health and Science University, Portland, OR, USA.
7
Northeastern University, Boston, MA, USA.
8
Placental Analytics, New Rochelle, NY, USA.
9
Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
10
University of California San Francisco, San Francisco, CA, USA.
11
Johns Hopkins University, Baltimore, MD, USA.
12
University of California Berkeley, Berkeley, CA, USA.

Abstract

Exposures to environmental chemicals and psychosocial stressors during pregnancy have been individually associated with adverse perinatal outcomes related to birthweight and gestational age, but are not often considered in combination. We review types of psychosocial stressors and instruments used to assess them and classes of environmental chemical exposures that are known to adversely impact perinatal outcomes, and identify studies relevant studies. We discuss the National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) program that has combined existing longitudinal cohorts that include more than 50,000 children across the U.S. We describe future opportunities for investigators to use this important new resource for addressing relevant and critical research questions to maternal health. Of the 84 cohorts in ECHO, 38 collected data on environmental chemicals and psychosocial stressors and perinatal outcomes. The diverse ECHO pregnancy cohorts provide capacity to compare regions with distinct place-based environmental and social stressors.

PMID:
31616048
DOI:
10.1038/s41372-019-0510-y

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