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Front Biosci (Landmark Ed). 2020 Jan 1;25:452-462.

mir-1 inhibits migration of gastric cancer cells.

Author information

1
Department of Gastroenterology, The First affiliated hospital of Wenzhou medical University, 325000, China.
2
Department of Gastroenterology, The First affiliated hospital of Wenzhou medical University, jlq2rf4t4bs4@sina.com.

Abstract

Gastric cancer is the fourth most common malignancy world-wide that bears a high mortality by invasiveness and metastases. To this end, we examined the role of miR-1 in mobility and migration of gastric cancer cells. miR-1 was down-regulated and Sorcin, which supports invasion, was highly expressed in gastric cancer cell lines as compared to the control. The overexpression of miR-1 significantly inhibited the mobility and migration of gastric cancer cells, while, its knockdown exerted an oppoiste effect. In addition, while overexpression of miR-1 suppressed the expression of Sorcin, the siRNA knockdown of Sorcin significantly counteracted the effect of miR-1 inhibitor on cell invasion and migration of gastric cancer cells. A miR-1 mimic decreased while its inhibitor increased the MMP-7 and VEGF required for invasion. Taken together, the findings support the view that miR-1 controls the mobility and migration of gastric cancer cells and might be a therapeutic target for blocking gastric cancer invasion.

PMID:
31585896

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