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Front Biosci (Landmark Ed). 2020 Jan 1;25:118-133.

Drosophila melanogaster as a model for understanding polyADP-ribosylation.

Author information

1
Nagahama Institute of Bio-Science and Technology, Nagahama Shiga 526-0829, Japan, m_miwa@nagahama-i-bio.ac.jp.
2
Institute of Basic Biological Sciences, University of Tsukuba, Tsukuba Ibaraki 305-8575, Japan.
3
Nagahama Institute of Bio-Science and Technology, Nagahama Shiga 526-0829, Japan.
4
Center for Chronic Viral Diseases, Kagoshima University, Kagoshima, Kagoshima 890-8544, Japan.

Abstract

PolyADP-ribosylation is a post-translational modification which is involved in various physiological processes including maintenance of genome stability through DNA repair, regulation of transcription, and development. This process is also involved in pathological events such as cell death. Here, we review the effect of polyADP-ribosylation in signal transduction pathways in Drosophila melanogaster system. It is hoped that such an insight paves the way to develop therapeutics for human diseases.

PMID:
31585880

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