Format

Send to

Choose Destination
PeerJ. 2019 Sep 26;7:e7778. doi: 10.7717/peerj.7778. eCollection 2019.

Transcriptome association studies of neuropsychiatric traits in African Americans implicate PRMT7 in schizophrenia.

Author information

1
Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL, USA.
2
Department of Biology, Loyola University Chicago, Chicago, IL, USA.
3
Program in Bioinformatics, Loyola University Chicago, Chicago, IL, USA.
4
Department of Computer Science, Loyola University Chicago, Chicago, IL, USA.
5
Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.

Abstract

In the past 15 years, genome-wide association studies (GWAS) have provided novel insight into the genetic architecture of various complex traits; however, this insight has been primarily focused on populations of European descent. This emphasis on European populations has led to individuals of recent African descent being grossly underrepresented in the study of genetics. With African Americans making up less than 2% of participants in neuropsychiatric GWAS, this discrepancy is magnified in diseases such as schizophrenia and bipolar disorder. In this study, we performed GWAS and the gene-based association method PrediXcan for schizophrenia (n = 2,256) and bipolar disorder (n = 1,019) in African American cohorts. In our PrediXcan analyses, we identified PRMT7 (P = 5.5 × 10-6, local false sign rate = 0.12) as significantly associated with schizophrenia following an adaptive shrinkage multiple testing adjustment. This association with schizophrenia was confirmed in the much larger, predominantly European, Psychiatric Genomics Consortium. In addition to the PRMT7 association with schizophrenia, we identified rs10168049 (P = 1.0 × 10-6) as a potential candidate locus for bipolar disorder with highly divergent allele frequencies across populations, highlighting the need for diversity in genetic studies.

KEYWORDS:

Bipolar disorder; GWAS; Gene expression; Population genetics; PrediXcan; Schizophrenia

Supplemental Content

Full text links

Icon for PeerJ, Inc. Icon for PubMed Central
Loading ...
Support Center