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Curr Opin Immunol. 2019 Sep 23;61:60-68. doi: 10.1016/j.coi.2019.08.006. [Epub ahead of print]

Shared and unique immune alterations in pre-clinical autoimmunity.

Author information

1
Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
2
Medicine and Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, United States.
3
Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States; Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States. Electronic address: Judith-James@omrf.org.

Abstract

Progression from health to a classified autoimmune disease is an evolving process that can happen rapidly in some diseases, but usually takes years to develop. Specific immune alterations predate pathogenic autoimmunity and can be used as disease biomarkers to identify high-risk individuals for prevention studies applied in the pre-clinical state. Here we discuss recent findings that illuminate specific immune pathways that are altered in the earliest phases of pre-clinical autoimmunity as well as those mediators more closely associated with later clinically apparent and classified disease onset.

PMID:
31557691
DOI:
10.1016/j.coi.2019.08.006

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