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Vaccine. 2019 Oct 8;37(43):6271-6275. doi: 10.1016/j.vaccine.2019.08.066. Epub 2019 Sep 11.

Anal human papillomavirus infections in young unvaccinated men who have sex with men attending a sexual health clinic for HPV vaccination in Melbourne, Australia.

Author information

1
Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia; Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia. Electronic address: eric.chow@monash.edu.
2
Murdoch Children's Research Institute, Parkville, VIC, Australia; Centre for Women's Infectious Disease Research, The Royal Women's Hospital, Parkville, VIC, Australia. Electronic address: jennifer.danielewski@mcri.edu.au.
3
Murdoch Children's Research Institute, Parkville, VIC, Australia; Centre for Women's Infectious Disease Research, The Royal Women's Hospital, Parkville, VIC, Australia. Electronic address: gerald.murray@mcri.edu.au.
4
Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia. Electronic address: gfehler@mshc.org.au.
5
Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia; Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia. Electronic address: mchen@mshc.org.au.
6
Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia; Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia. Electronic address: cbradshaw@mshc.org.au.
7
Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Obstetrics Gynaecology, University of Melbourne, Parkville, VIC, Australia. Electronic address: suzanne.garland@thewomens.org.au.
8
Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia; Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia. Electronic address: cfairley@mshc.org.au.

Abstract

The Victorian Government introduced a time-limited quadrivalent human papillomavirus (HPV) vaccination catch-up program targeting gay and bisexual men who have sex with men (MSM) aged up to 26 years in 2017. As of 2017, men aged ≥20 years were not eligible for the school-based HPV vaccination program. This study examined the prevalence of anal HPV among 496 MSM aged 20-26 years before they received the first dose of the HPV vaccine at the Melbourne Sexual Health Centre, Australia. More than half (56.5%) had any high-risk HPV genotypes detected in the anus. Almost half (43.1%) had at least one quadrivalent HPV vaccine-preventable genotype (6, 11, 16 or 18) and one-fifth (21.0%) had HPV 16 detected in the anus. These findings suggest that a targeted catch-up HPV vaccination program for MSM is still beneficial to protect against high-risk HPV genotypes associated with anal cancer, as well as low-risk HPV genotypes.

KEYWORDS:

Anal; Cancer; Catch-up program; Gay men; HPV; Homosexual; Human papillomavirus; MSM; Prevention; Vaccination; Vaccine

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