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Sci Immunol. 2019 Sep 13;4(39). pii: eaay7668. doi: 10.1126/sciimmunol.aay7668.

Germinal center TFH cells: T(w)o be or not t(w)o be, IL-6 is the answer.

Zhou P1, Liang K2, Yu D3,2,4.

Author information

1
Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
2
China-Australia Centre for Personalized Immunology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
3
Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia. di.yu@anu.edu.au.
4
Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, Shandong, China.

Abstract

IL-6 inhibits the expression of IL-2Rβ (CD122) in germinal center TFH cells to maintain IL-2 hyporesponsiveness (see the related Research Article by Papillion et al.).

PMID:
31519813
DOI:
10.1126/sciimmunol.aay7668

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