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Nat Commun. 2019 Sep 6;10(1):4021. doi: 10.1038/s41467-019-12002-1.

Auxin-sensitive Aux/IAA proteins mediate drought tolerance in Arabidopsis by regulating glucosinolate levels.

Author information

1
Section of Cell and Developmental Biology and Howard Hughes Medical Institute, University of California, San Diego, La Jolla CA., 92093, USA.
2
Department of Plant Sciences, University of California, Davis, CA, 95616, USA.
3
Genomic Analysis Laboratory, Howard Hughes Medical Institute and The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.
4
Section of Cell and Developmental Biology and Howard Hughes Medical Institute, University of California, San Diego, La Jolla CA., 92093, USA. mestelle@ucsd.edu.

Abstract

A detailed understanding of abiotic stress tolerance in plants is essential to provide food security in the face of increasingly harsh climatic conditions. Glucosinolates (GLSs) are secondary metabolites found in the Brassicaceae that protect plants from herbivory and pathogen attack. Here we report that in Arabidopsis, aliphatic GLS levels are regulated by the auxin-sensitive Aux/IAA repressors IAA5, IAA6, and IAA19. These proteins act in a transcriptional cascade that maintains expression of GLS levels when plants are exposed to drought conditions. Loss of IAA5/6/19 results in reduced GLS levels and decreased drought tolerance. Further, we show that this phenotype is associated with a defect in stomatal regulation. Application of GLS to the iaa5,6,19 mutants restores stomatal regulation and normal drought tolerance. GLS action is dependent on the receptor kinase GHR1, suggesting that GLS may signal via reactive oxygen species. These results provide a novel connection between auxin signaling, GLS levels and drought response.

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