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Hum Immunol. 2019 Nov;80(11):923-929. doi: 10.1016/j.humimm.2019.08.004. Epub 2019 Aug 23.

A survey of known immune epitopes in the enteroviruses strains associated with acute flaccid myelitis.

Author information

1
Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA. Electronic address: agrifoni@lji.org.
2
Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
3
Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; J. Craig Venter Institute, La Jolla, CA 92037, USA; Department of Pathology, University of California, San Diego, CA 92093, USA.
4
Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California, San Diego, CA 92093, USA.

Abstract

Enteroviruses are potentially linked to the emergence of Acute Flaccid Myelitis (AFM), a rare but very serious condition that affects the nervous system. AFM has been associated with coxsackievirus A16, enterovirus A71 (EVA71) and enterovirus D68 (EVD68). Little is known about host-pathogen interactions for these viruses, and whether immune responses may have a protective or immunopathological role in disease presentations. Towards addressing this issue, we used the Immune Epitope Database to assess the known inventory of B and T cell epitopes from enteroviruses, focusing on data related to human hosts. The extent of conservation in areas that are targets of B and T cell immune responses were examined. This analysis sheds light on regions of the enterovirus polypeptide that can be probed to induce a specific or cross-reactive B or T cell the immune response to enteroviruses, with a particular focus on coxsackievirus A16, EVA71 and EVD68. In addition, these analyses reveal the current gap-of-knowledge in the T and B cell immune responses that future studies should aim to address.

KEYWORDS:

AFM; B cells; Enteroviruses; Epitopes; T cells

PMID:
31451291
PMCID:
PMC6876747
[Available on 2020-11-01]
DOI:
10.1016/j.humimm.2019.08.004

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