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Trends Cancer. 2019 Aug;5(8):475-494. doi: 10.1016/j.trecan.2019.07.002. Epub 2019 Aug 3.

Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment.

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The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Medicine, Division of Regenerative Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA; Scintillon Institute, San Diego, CA 92121, USA. Electronic address:
The Salk Institute for Biological Studies, La Jolla, CA, USA; Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, 9300 Campus Point Drive, La Jolla, CA 92037, USA.
The Salk Institute for Biological Studies, La Jolla, CA, USA. Electronic address:


Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a key role in tumorigenesis and facilitates the establishment of cancer hallmarks. Conversely, oncogenic processes directly weaken circadian rhythms. Pharmacological modulation of core clock genes is a new approach in cancer therapy. The integration of circadian biology into cancer research offers new options for making cancer treatment more effective, encompassing the prevention, diagnosis, and treatment of this devastating disease. This review highlights the role of the circadian clock in tumorigenesis and cancer hallmarks, and discusses how pharmacological modulation of circadian clock genes can lead to new therapeutic options.


cancer hallmarks; cancer therapy; circadian clock; circadian rhythms; tumorigenesis

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