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BMC Infect Dis. 2019 Aug 5;19(1):688. doi: 10.1186/s12879-019-4322-7.

Risk factors for viral hepatitis C infection in Rwanda: results from a nationwide screening program.

Author information

1
IHDPC Department, Rwanda Biomedical Center, Po Box 7162, Kigali, Rwanda. makorofr@gmail.com.
2
Health Department, Clinton Health Access Initiative (CHAI), Kigali, Rwanda.
3
IHDPC Department, Rwanda Biomedical Center, Po Box 7162, Kigali, Rwanda.
4
School of Population and Public Health, University of British Columbia, Vancouver, Canada.
5
Division of Global Health Equity, Brigham & Women's Hospital, Boston, USA.
6
Department of Infectious Disease at the Alfred Hospital and Infectious Diseases Epidemiology, Monash University in Melbourne, Melbourne, Australia.

Abstract

BACKGROUND:

The epidemiology and risk factors for hepatitis C virus (HCV) infection in Rwanda are not well known; however, this information is crucial to shaping the country's public health approach to hepatitis C control.

METHODS:

A HCV screening campaign was conducted in the general population in 24 districts previously identified to have a high HCV disease burden. At the time of sample collection, sociodemographic information and self-reported risk factors were collected. Bivariate and multivariate logistic regressions were conducted to assess risk factors independently associated with hepatitis C antibodies (HCVAb) seroprevalence.

RESULTS:

Out of a total of 326,263 individuals screened for HCVAb, 22,183 (6.8%) were positive. In multivariate analysis, risk factors identified as statistically associated with HCVAb Seroprevalence include history of traditional operation or scarification (OR = 1.09, 95% CI: 1.05-1.14), presence of viral hepatitis in the family (OR = 1.27, 95% CI: 1.15-1.40), widowed or separated/divorced (OR = 1.36, 95% CI: 1.26-1.47), Southern province (OR = 1.98, 95% CI: 1.88-2.08) and aged 65 years and older (OR = 4.86, 95% CI: 4.62-5.11). Ubudehe category 3 (OR = 0.97, 95% CI: 0.93-1.01) and participants using RAMA (Health insurances for employees of public and private sectors) insurance (OR = 0.76, 95% CI: 0.70-0.85) had lower odds of HCV seroprevalence.

CONCLUSIONS:

Our findings provide important information for Rwanda's strategy on prevention and case-finding. Future prevention interventions should aim to reduce transmission through targeted messaging around traditional healing practices and case-finding targeting individuals with a history of exposure or advanced age.

KEYWORDS:

Risk factors; Rwanda; Viral hepatitis C

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