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Turk J Obstet Gynecol. 2019 Jun;16(2):100-106. doi: 10.4274/tjod.galenos.2019.51482. Epub 2019 Jul 3.

Increased nuchal translucency and pregnancy outcomes: experience of Başkent University Ankara Hospital.

Author information

Başkent University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey.
Başkent University Faculty of Medicine, Department of Medical Genetics, Ankara, Turkey.



First trimester nuchal translucency (NT) measurement is considered to be an important tool in antenatal follow-up. This study aimed to evaluate the outcomes of pregnancies with increased NT at Başkent University Ankara Hospital between 2004 and 2016.

Materials and Methods:

Patients with NT measurements ≥1.5 multiples of median (MoM) were divided into two groups; group I included increased NT cases without fetal anomalies (either abnormal fetal karyotype or congenital structural anomalies) or loss (intrauterine fetal death), and group II included increased NT cases with fetal anomalies or loss. The groups were compared with each other with respect to maternal demographic features and NT measurements.


Karyotype analyses were normal in 73.1% of cases with increased NT (57/78). Among those, 21.1% (12/57) had structural anomalies, and to specify, 9.6% (5/52 over 18 weeks) had cardiac anomalies. Although maternal demographic features did not differ significantly, NT measurements, both as millimeters and MoM, were significantly higher in group II (p<0.05). According to the receiver operating characteristic (ROC) curves, the optimal cut-off values for NT measurements for predicting fetal anomalies or loss were 3.05 mm and 2.02 MoM. NT measurement >7 millimeters or NT MoM >4.27 resulted in poor fetal outcomes without exception.


Higher NT measurements indicate poorer pregnancy outcomes. Our study indicates that fetal echocardiography must be considered for all cases with increased NT.


abnormal karyotype; cardiac anomaly; Nuchal translucency

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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