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Turk J Obstet Gynecol. 2019 Jun;16(2):91-94. doi: 10.4274/tjod.galenos.2019.40460. Epub 2019 Jul 3.

Evaluation of serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia.

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1
Marmara University Faculty of Medicine, Department of Obstetrics and Gynecology, İstanbul, Turkey.

Abstract

Objective:

The aim of the study was to assess serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia.

Materials and Methods:

One hundred forty pregnant women were enrolled in the study, of which 100 subjects were preeclamptic and 40 were healthy controls. Serum concentrations of cathepsin B, D, and L were measured and compared between the preeclamptic and control groups.

Results:

Cathepsin B and D concentrations were significantly higher in the preeclamptic group compared with the control group. There was no statistically significant difference between the groups in terms of cathepsin L concentrations. Cathepsin B concentrations were significantly higher in women with preeclampsia with severe features compared with those with preeclampsia alone.

Conclusion:

Women with late-onset preeclampsia have significantly higher serum cathepsin B and D concentrations than controls. Cathepsin B and D may be promising biomarkers in women with late-onset preeclampsia.

KEYWORDS:

Cathepsin B; cathepsin D; cathepsin L; preeclampsia

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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