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J Clin Res Pediatr Endocrinol. 2020 Mar 19;12(1):29-36. doi: 10.4274/jcrpe.galenos.2019.2019.0072. Epub 2019 Jul 24.

Can Nesfatin-1 Predict Hypertension in Obese Children?

Author information

1
Sütçü İmam University Faculty of Medicine, Department of Pediatrics, Kahramanmaraş, Turkey
2
Sütçü İmam University Faculty of Medicine, Department of Biochemistry, Kahramanmaraş, Turkey
3
Sütçü İmam University Faculty of Medicine, Department of Cardiology, Kahramanmaraş, Turkey
4
Sütçü İmam University Faculty of Medicine, Department of Pediatric Endocrinology and Metabolism, Kahramanmaraş, Turkey

Abstract

Objective:

The prevalence of childhood obesity is increasing and leads to co-morbidities such as hypertension. However, it is still not clear why some obese individuals are hypertensive and others not. Nesfatin-1 is a recently discovered anorexigenic peptide which also has effects on blood pressure (BP). Our aim was to evaluate the relationship between obesity-related hypertension and Nesfatin-1.

Methods:

This cross-sectional study comprised 87 obese children. The patients were divided into two groups; hypertensive (n=30) and normotensive (n=57) obese. The American Academy of Pediatrics guidelines were used to diagnose hypertension. Blood samples were collected after 12 hours of fasting to investigate Nesfatin-1 concentrations. We also evaluated serum trace elements in addition to the routine blood tests.

Results:

Body mass index (BMI), weight and serum Nesfatin-1 concentrations were higher in the hypertensive group (p=0.002, p=0.001, and p=0.007, respectively). There was no difference between serum zinc levels, but Copper (Cu) levels were significantly lower in the hypertensive group (p=0.248, p=0.007, respectively). There were positive correlations between BP and BMI and weight Z-scores and a negative correlation with Cu. The optimal cut-off value of Nesfatin-1 to predict hypertension was found to be >1.8 ng/mL, with a specificity of 71.9% and a sensitivity of 96.7% [area under the curve=0.703, 95% confidence interval (CI): 0.577-0.809; p=0.002]. In multiple logistic regression analysis Nesfatin-1 [Odds ratio (OR)=1.103, 95% CI: 1.039-1.171; p=0.001], Cu (OR=0.947, 95% CI: 0.915-0.979; p=0.001) and BMI for age Z-score (OR=56.277, 95% CI: 5.791-546.907; p=0.001) still remained significant predictors of hypertension.

Conclusion:

Nesfatin-1 levels are higher and are an independent predictor of hypertension in obese subjects.

KEYWORDS:

Obesity; hypertension; Nesfatin-1; children

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