Send to

Choose Destination
BMJ Case Rep. 2019 Jul 17;12(7). pii: e229388. doi: 10.1136/bcr-2019-229388.

Proton beam therapy for malignant transformation of intracranial epidermoid cyst.

Author information

Radiology, University of Yamanashi Faculty of Medicine, Chuo, Yamanashi, Japan.
Proton Therapy Centre, Aizawa Hospital, Matsumoto, Nagano, Japan.


We report the first clinical case on the successful use of proton beam therapy in the management of malignant transformation of intracranial epidermoid cyst. A 43-year-old man was initially diagnosed as this disease with left facial paresis, hypesthesia and hypoalgesia in the territories of the trigeminal nerve. After failure of surgical interventions, he was referred to our radiation centre. We performed a postoperative proton beam therapy for treatment. We delivered a total dose of 57 GyE in 31 fractions. He tolerated the treatment well with mild acute toxicities and remained healthy and functional by 2-year follow-up postradiotherapy. No evidence of delayed radiation-induced neurotoxicity was observed.


neurooncology; neurosurgery; radiology


Conflict of interest statement

Competing interests: None declared.

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center