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Trends Parasitol. 2019 Aug;35(8):622-635. doi: 10.1016/j.pt.2019.06.002. Epub 2019 Jul 4.

Babesiosis Vaccines: Lessons Learned, Challenges Ahead, and Future Glimpses.

Author information

1
Department of Microbiology, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia.
2
Program in Vector-Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, USA.
3
Program in Vector-Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, USA; Animal Disease Research Unit, Agricultural Research Service, USDA, WSU, Pullman, WA, USA.
4
Department of Microbiology, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia. Electronic address: brian.cooke@monash.edu.

Abstract

The incidence and prevalence of babesiosis in animals and humans is increasing, yet prevention, control, or treatment measures remain limited and ineffective. Despite a growing body of new knowledge of the biology, pathogenicity, and virulence of Babesia parasites, there is still no well-defined, adequately effective and easily deployable vaccine. While numerous published studies suggest that the development of such anti-Babesia vaccines should be feasible, many others identify significant challenges that need to be overcome in order to succeed. Here, we review historic and recent attempts in babesiosis vaccine discovery to avoid past pitfalls, learn new lessons, and provide a roadmap to guide the development of next-generation babesiosis vaccines.

KEYWORDS:

Babesia; antigen discovery; babesiosis; immune responses; subunit vaccines; vaccine development

PMID:
31281025
DOI:
10.1016/j.pt.2019.06.002

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