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Trends Immunol. 2019 Aug;40(8):735-747. doi: 10.1016/j.it.2019.06.002. Epub 2019 Jun 26.

Tissue-Resident Memory T Cells in Cancer Immunosurveillance.

Author information

1
Department of Microbiology & Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
2
Department of Microbiology & Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia. Electronic address: lkmackay@unimelb.edu.au.

Abstract

Following their activation and expansion in response to foreign threats, many T cells are retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8+ memory T (TRM) cells patrol barrier surfaces and nonlymphoid organs, where their critical role in protecting against viral and bacterial infections is well established. Recent evidence suggests that TRM cells also play a vital part in preventing the development and spread of solid tumors. Here, we discuss the emerging role of TRM cells in anticancer immunity. We highlight defining features of tumor-localizing TRM cells, examine the mechanisms through which they have recently been shown to suppress cancer growth, and explore their potential as future targets of cancer immunotherapy.

PMID:
31255505
DOI:
10.1016/j.it.2019.06.002

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