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ACS Infect Dis. 2019 Aug 9;5(8):1269-1278. doi: 10.1021/acsinfecdis.9b00093. Epub 2019 Jun 20.

Post-Genomic Approaches to Understanding Malaria Parasite Biology: Linking Genes to Biological Functions.

Author information

1
Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences , Monash University , 381 Royal Parade , Parkville , VIC 3052 , Australia.
2
Centre for Chronic, Inflammatory and Infectious Diseases, Biomedical Sciences Cluster, School of Health and Biomedical Sciences , RMIT University , 264 Plenty Road , Bundoora , VIC 3083 , Australia.
3
Molecular Parasitology Laboratory, Department of Physiology, Anatomy and Microbiology , La Trobe University , Kingsbury Drive , Bundoora , VIC 3086 , Australia.

Abstract

Plasmodium species are evolutionarily distant from model eukaryotes, and as a consequence they exhibit many non-canonical cellular processes. In the post-genomic era, functional "omics" disciplines (transcriptomics, proteomics, and metabolomics) have accelerated our understanding of unique aspects of the biology of malaria parasites. Functional "omics" tools, in combination with genetic manipulations, have offered new opportunities to investigate the function of previously uncharacterized genes. Knowledge of basic parasite biology is fundamental to understanding drug modes of action, mechanisms of drug resistance, and relevance of vaccine candidates. This Perspective highlights recent "omics"-based discoveries in basic biology and gene function of the most virulent human malaria parasite, Plasmodium falciparum.

KEYWORDS:

; genetic manipulation; malaria; putative genes; systems biology; “omics”

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