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J Exp Med. 2019 Jun 24. pii: jem.20191002. doi: 10.1084/jem.20191002. [Epub ahead of print]

The nature of human IL-6.

Puel A1,2, Casanova JL3,2,4,5,6.

Author information

1
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France anne.puel@inserm.fr.
2
Paris Descartes University, Imagine Institute, Paris, France.
3
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France Jean-Laurent.Casanova@rockefeller.edu.
4
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
5
Howard Hughes Medical Institute, New York, NY.
6
Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, Paris, France.

Abstract

Countless functions have been attributed experimentally to IL-6. In this issue of JEM, Spencer et al. (https://doi.org/10.1084/jem.20190344) reveal essential, nonredundant functions of human IL-6. Patients with genetic deficiencies of the IL-6 receptor suffer from "hyper IgE syndrome."

PMID:
31235508
DOI:
10.1084/jem.20191002

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