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J Pediatric Infect Dis Soc. 2019 Jun 13. pii: piz038. doi: 10.1093/jpids/piz038. [Epub ahead of print]

Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment.

Author information

1
Seattle Children's Research Institute, Washington.
2
Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
3
University of Zimbabwe College of Health Sciences, Harare.
4
Centre for Infectious Disease Research in Zambia, Lusaka.
5
University of Alabama at Birmingham, Alabama.
6
University of California, San Diego, La Jolla.
7
Northwestern University Feinberg School of Medicine, Chicago, Illinois.
8
University of Washington, Seattle.

Abstract

Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of ART. Pre-ART NNRTI resistance was not associated with virologic failure.

KEYWORDS:

HIV drug resistance; HIV-infected children; HIV/TB coinfection; NNRTI resistance; efavirenz

PMID:
31194860
DOI:
10.1093/jpids/piz038

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