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J Autoimmun. 2019 Sep;103:102283. doi: 10.1016/j.jaut.2019.05.011. Epub 2019 May 24.

Different patterns and specific outcomes of large-vessel involvements in giant cell arteritis.

Author information

1
Department of Internal Medicine, Caen University Hospital, Caen, France; Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000, Caen, France. Electronic address: deboysson-h@chu-caen.fr.
2
Department of Internal Medicine and Clinical Immunology, Limoges University Hospital, Limoges, France.
3
Department of Internal Medicine, Nantes University Hospital, Nantes, France.
4
Department of Internal Medicine and Therapeutics, Timone Hospital, Marseille, France.
5
AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Centre de Référence des Maladies Auto-Immunes et Systémiques Rares, Centre de Référence des Maladies Auto-Inflammatoires, Paris, France.
6
Department of Internal Medicine, Lille University Hospital, Lille, France.
7
Biostatistics and Clinical Research Unit, Caen University Hospital, France.
8
Department of Internal Medicine, Caen University Hospital, Caen, France.
9
Department of Nuclear Medicine, Caen University Hospital, Caen, France.
10
AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Centre de Référence des Maladies Auto-Immunes et Systémiques Rares, Centre de Référence des Maladies Auto-Inflammatoires, Paris, France; Sorbonne Université;s, UPMC Univ Paris 06, Inflammation-Immunopathology-Biotherapy Department, France; INSERM, Paris, France; CNRS, Paris, France.
11
Department of Internal Medicine, Caen University Hospital, Caen, France; Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000, Caen, France.

Abstract

Large-vessel involvement (LVI) in giant cell arteritis (GCA) includes different clinical and imaging patterns that are rarely described separately at diagnosis and whose specific cardiovascular outcomes are unknown. We conducted a nationwide retrospective study and included GCA patients with LVI demonstrated on imaging at diagnosis between 2007 and 2017. We analyzed the prognosis of three different imaging patterns of LVI present at diagnosis, with some of them overlapping but with the first one present in all patients: 1) inflammation of the aorta and/or its branches; 2) dilation of the aorta; and 3) stenosis of the aortic branches. A control group of GCA patients without LVI was constituted. We included 183 patients with LVI and 105 controls without LVI. Altogether, among the 183 patients who all showed inflammation of the aorta and/or its main branches, concomitant aortic dilation and large-vessel stenosis were observed in 27 (15%) and 55 (30%) patients, respectively. During the follow-up period, new cardiovascular events occurred in 49% and 11% of LVI patients and controls, respectively (p < 0.0001). Inflammation of the aorta and/or its branches (HR: 3.42 [2.09-5.83], p < 0.0001) and large-artery stenosis (HR: 2.75 [1.80-4.15], p < 0.0001) were independent predictive factors of new cardiovascular events. Conversely, the use of an immunosuppressant besides corticosteroids was a protective factor against new cardiovascular events (HR: 0.44 [0.29-0.66], p < 0.0001) and the development of aortic dilation (HR: 0.43 [0.23-0.77], p = 0.005). This study suggests different forms of cardiovascular events according to the initial imaging pattern of LVI.

KEYWORDS:

Aortic dilation; Aortic dissection; Cardiovascular outcomes; Giant-cell arteritis; Imaging patterns; Large-vessel stenosis

PMID:
31130367
DOI:
10.1016/j.jaut.2019.05.011

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