Format

Send to

Choose Destination
Int J Mol Sci. 2019 May 9;20(9). pii: E2307. doi: 10.3390/ijms20092307.

Influence of a Novel Surface of Bioactive Implants on Osseointegration: A Comparative and Histomorfometric Correlation and Implant Stability Study in Minipigs.

Author information

1
Advanced Periodontics, Facultad de Odontología, Universidad de Sevilla, C/Avicena S/N 41009 Seville, Spain. mmromero@infomed.es.
2
Technological Health Research Center, Biomaterials of the Faculties of Medicine and Dentistry, International University of Cataluña, 08034 Barcelona, Spain. xavier.gil@uic.es.
3
Advanced Periodontics, Facultad de Odontología, Universidad de Sevilla, C/Avicena S/N 41009 Seville, Spain. jvrios@us.es.
4
Advanced Periodontics, Facultad de Odontología, Universidad de Sevilla, C/Avicena S/N 41009 Seville, Spain. pedro@lazarocalvo.com.
5
Advanced Periodontics, Facultad de Odontología, Universidad de Sevilla, C/Avicena S/N 41009 Seville, Spain. brios@us.es.
6
Porto Dental Institute, 4150-518 Oporto, Portugal. dr.herrero@herrerocliment.com.

Abstract

PURPOSE:

The objective of this study was to assess the influence of a novel surface of dental implants (ContacTi®) on the osseointegration process in a minipig model. The surface was compared with other existing surfaces on the market (SLA® and SLActive®) by employing bone implant contact analysis (BIC) and implant stability.

METHOD:

Twelve minipigs were used with prior authorisation from an ethics committee. Three types of surfaces were tested: SLA® (sand-blasted acid-etched titanium), SLActive® (same but hydrophilic, performed under a nitrogen atmosphere), and ContacTi® (alumina particle bombardment of titanium, bioactivated when treated thermochemically) in 4.1 mm × 8 mm implants with internal connection and a polished neck. Twelve implants of each surface type (N = 36) were placed, sacrificing 1/3 of the animals at 2 weeks of placement, 1/3 at 4 weeks and the remaining 1/3 at 8 weeks. Numerical variables were compared with Analysis of Variance, and the correlation between ISQ and BIC was established with the Spearman's rank correlation coefficient.

RESULTS:

SLActive® and ContacTi® surfaces showed elevated osteoconductivity at 4 weeks, maintaining a similar evolution at 8 weeks (large amount of mature lamellar tissue with high maturity and bone quality). The SLA® surface showed slower maturation. The ISQ values in surgery were elevated (above 65), higher at necropsy and higher at 4 and 8 weeks in the SLA® group than in the other two (SLActive® and ContacTi®). No significant correlation was found between ISQ and BIC for each implant surface and necropsy time.

CONCLUSION:

The three surfaces analysed showed high RFA and BIC values, which were more favourable for the SLActive® and ContacTi® surfaces. No statistical correlation was found between the RFA and BIC values in any of the three surfaces analysed.

KEYWORDS:

Bioactive Implants; Histomorfometric analytic; Implant surface; Oral implants; minipigs

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center