Nummular dermatitis on guselkumab for palmoplantar psoriasis

Dermatol Ther. 2019 Jul;32(4):e12954. doi: 10.1111/dth.12954. Epub 2019 May 20.

Abstract

A 40-year-old man with chronic history of refractory palmoplantar psoriasis presented with new onset of well-demarcated oval erythematous asteatotic plaques on bilateral shins after starting guselkumab therapy. Histopathology revealed chronic spongiotic dermatitis consistent with a diagnosis of nummular dermatitis. This case highlights a previously unreported adverse event to guselkumab therapy.

Keywords: IL23; Th17; dermatitis; guselkumab; nummular; palmoplantar; psoriasis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Monoclonal, Humanized / administration & dosage
  • Antibodies, Monoclonal, Humanized / adverse effects*
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / adverse effects*
  • Drug Eruptions / diagnosis
  • Drug Eruptions / etiology*
  • Humans
  • Male
  • Psoriasis / drug therapy*

Substances

  • Antibodies, Monoclonal, Humanized
  • Dermatologic Agents
  • guselkumab