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Semin Cell Dev Biol. 2019 May 2. pii: S1084-9521(18)30322-7. doi: 10.1016/j.semcdb.2019.04.015. [Epub ahead of print]

Tailored chromatin modulation to promote tissue regeneration.

Author information

1
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, United States.
2
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, United States. Electronic address: belmonte@salk.edu.

Abstract

Epigenetic regulation of gene expression is fundamental in the maintenance of cellular identity and the regulation of cellular plasticity during tissue repair. In fact, epigenetic modulation is associated with the processes of cellular de-differentiation, proliferation, and re-differentiation that takes place during tissue regeneration. In here we explore the epigenetic events that coordinate tissue repair in lower vertebrates with high regenerative capacity, and in mammalian adult stem cells, which are responsible for the homeostasis maintenance of most of our tissues. Finally we summarize promising CRISPR-based editing technologies developed during the last years, which look as promising tools to not only study but also promote specific events during tissue regeneration.

KEYWORDS:

Adult stem cells; CRISPR; DNA methylation; Epidermal stem cells; Epigenetic editing; Epigenetics; Genetic editing; Hematopoietic stem cells; Histone modifications; Intestinal stem cells; Muscle stem cells; Neural stem cells; Regeneration

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