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FEBS Open Bio. 2019 May;9(5):947-958. doi: 10.1002/2211-5463.12625. Epub 2019 Mar 30.

Sexual dimorphisms in the transcriptomes of murine salivary glands.

Author information

1
Secretory Mechanisms and Dysfunctions Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
2
Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Fukuoka, Japan.
3
Joint Institute for Food Safety and Applied Nutrition, University of Maryland, College Park, MD, USA.
4
Department of Pediatric Dentistry, Beijing Stomatological Hospital & School of Stomatology, Capital Medical University, Beijing, China.
5
Department of Prosthodontics, Matsumoto Dental University, Shiojiri, Japan.

Abstract

Transcriptional profiling identified 933 sexually dimorphic genes out of the 14 371 protein-coding genes expressed in the three major murine salivary glands: parotid, sublingual, and submandibular. Most (89%) sex-specific genes were enriched in a single gland, while only 0.5% of the sexually dimorphic genes were enriched in all glands. The sublingual gland displayed a strong male sex bias (94% of sex-enriched genes), while a sex preference was not obvious in the parotid or submandibular glands. A subset of transcription factor genes was correlated with the expression of gland-specific, sex-enriched genes. Higher expression of Cftr chloride and Scnn1 sodium channels in the male submandibular correlated with greater NaCl reabsorption. In conclusion, adult salivary glands display sex- and gland-specific differences in gene expression that reflect their unique functional properties.

KEYWORDS:

Cftr; ENaC; NaCl reabsorption; RNA-seq; salivary gland; sexual dimorphism

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