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Curr Opin Struct Biol. 2019 Jun;56:164-170. doi: 10.1016/j.sbi.2019.03.010. Epub 2019 Apr 13.

Molecular recognition of nucleosomes by binding partners.

Author information

1
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
2
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. Electronic address: panch@ncbi.nlm.nih.gov.

Abstract

Nucleosomes represent the elementary units of chromatin packing and hubs in epigenetic signaling pathways. Across the chromatin and over the lifetime of the eukaryotic cell, nucleosomes experience a broad repertoire of alterations that affect their structure and binding with various chromatin factors. Dynamics of the histone core, nucleosomal and linker DNA, and intrinsic disorder of histone tails add further complexity to the nucleosome interaction landscape. In light of our understanding through the growing number of experimental and computational studies, we review the emerging patterns of molecular recognition of nucleosomes by their binding partners and assess the basic mechanisms of its regulation.

PMID:
30991239
PMCID:
PMC6656623
[Available on 2020-06-01]
DOI:
10.1016/j.sbi.2019.03.010
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