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Semin Perinatol. 2019 Aug;43(5):282-290. doi: 10.1053/j.semperi.2019.03.018. Epub 2019 Mar 16.

An overview of malaria in pregnancy.

Author information

1
Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, United States. Electronic address: Melissa_bauserman@med.unc.edu.
2
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States.
3
Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, United States.
4
Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, United States.

Abstract

One hundred twenty-five million pregnant women are at risk for contracting malaria, a preventable cause of maternal and infant morbidity and death. Malaria parasites contribute to adverse pregnancy and birth outcomes due to their preferential accumulation in placental intervillous spaces. Pregnant women are particularly vulnerable to malaria infections, and malaria infections during pregnancy put their fetuses at risk. Malaria in pregnancy is associated with anemia, stillbirth, low birth weight and maternal and fetal death. We review the challenges to diagnosing malaria in pregnancy, as well as strategies to prevent and treat malaria in pregnancy. Finally, we discuss the current gaps in knowledge and potential areas for continued research.

KEYWORDS:

Africa; Asia; Malaria; Pregnancy

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