Non-invasive fungal sinusitis resulting in multiple cranial nerve neuropathies

BMJ Case Rep. 2019 Apr 8;12(4):e229094. doi: 10.1136/bcr-2018-229094.

Abstract

A 33-year-old man presented to the emergency department with a right-sided facial paralysis and maxillary division (V2, trigeminal nerve) paraesthesia. He had been suffering with upper respiratory tract symptoms in the preceding 2 months, including rhinorrhoea, fever and headache. The patient was otherwise fit and immunocompetent. Urgent radiological investigation revealed extensive fungal sinusitis with sphenoid sinus dehiscence and skull base osteitis. The patient underwent emergency endoscopic sinus surgery revealing concretions and debris in the ethmoid and sphenoid sinuses. He was commenced on systemic antifungal therapy and made a full recovery with resolution of his cranial neuropathies. The fungus Schizophyllum commune was isolated and is a rare cause of fungal sinusitis, but with the potential for invasive disease in immunosuppressed individuals.

Keywords: ear, nose and throat; ear, nose and throat/otolaryngology; otolaryngology / ENT.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use
  • Bone Diseases, Infectious / complications
  • Bone Diseases, Infectious / etiology*
  • Bone Diseases, Infectious / microbiology
  • Cranial Nerve Diseases / etiology*
  • Fluconazole / therapeutic use
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Mycoses / complications*
  • Mycoses / diagnosis
  • Mycoses / microbiology
  • Mycoses / therapy
  • Osteitis / etiology*
  • Osteitis / microbiology
  • Schizophyllum / isolation & purification
  • Sinusitis / complications*
  • Sinusitis / diagnosis
  • Sinusitis / microbiology
  • Sinusitis / therapy
  • Skull Base / diagnostic imaging
  • Skull Base / microbiology
  • Skull Base / pathology
  • Tomography, X-Ray Computed

Substances

  • Antifungal Agents
  • Fluconazole