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Head Neck. 2019 Mar 23. doi: 10.1002/hed.25742. [Epub ahead of print]

Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer.

Author information

1
Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
2
Online Research Club (http://www.onlineresearchclub.org/.
3
Faculty of Medicine, Minia University, Minia, Egypt.
4
Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.
5
University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
6
McMaster University, Hamilton, Ontario, Canada.
7
School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Selangor, Malaysia.
8
Sulaiman Al Rajhi Colleges, Al Bukayriya, Saudi Arabia.
9
Evidence Based Medicine Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
10
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
11
Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.

Abstract

BACKGROUND:

We aimed to investigate the prognostic role of examined (dissected) lymph nodes (ELNs), negative LNs (NLNs), and positive (metastatic) LNs (PLNs) counts and LN ratio (LNR = PLNs/ELNs×100) in patients with major salivary gland cancer (SGC).

METHODS:

Data were retrieved for major SGC patients diagnosed between 1988 and 2011 from Surveillance, Epidemiology, and End Results program.

RESULTS:

We have included 5446 patients with major SGC. Most patients had parotid gland cancer (84.61%). Patients having >18 ELNs, >4 PLNs, and >33.33% LNR were associated with a worse survival. Moreover, older age, male patients, grade IV, distant stage, unmarried patients, submandibular gland cancer, and received chemotherapy but not received surgery were significantly associated with a worse survival.

CONCLUSIONS:

We demonstrated that patients with >18 ELNs and >4 PLNs counts, and >33.33% LNR were high-risk group patients. We strongly suggest adding the ELNs and PLNs counts and/or LNR into the current staging system.

KEYWORDS:

SEER; lymph node; metastasis; ratio; salivary gland; survival

PMID:
30905082
DOI:
10.1002/hed.25742

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