Format

Send to

Choose Destination
PLoS One. 2019 Mar 12;14(3):e0213250. doi: 10.1371/journal.pone.0213250. eCollection 2019.

Brief report - Telomere length is a poor biomarker to predict 1-year mortality or cardiovascular comorbidity in patients with transcatheter aortic valve replacement.

Author information

1
Universitätsklinikum Essen, Klinik für Kardiologie und Angiologie, Essen, Germany.
2
Universitätsklinkum Bonn, Medizinische Klinik und Poliklinik II, Bonn, Germany.
3
Universitätsklinikum Frankfurt, Klinik für Kardiologie, Frankfurt, Germany.

Abstract

BACKGROUND:

Transcatheter aortic valve replacement (TAVR) is a therapeutic option for patients with aortic valve stenosis at increased surgical risk. Telomeres are an established marker for cellular senescence and have served to evaluate cardiovascular diseases including severe aortic valve stenosis. In our study, we hypothesized that telomere length may be a predictor for outcome and associated with comorbidities in patients with TAVR.

METHODS AND RESULTS:

We analyzed leucocyte telomere length from 155 patients who underwent TAVR and correlated the results with 1-year mortality and severe comorbidities. The cohort was subdivided into 3 groups according to telomere length. Although a trend for a positive correlation of telomere length with a lower EuroSCORE could be found, telomere length was not associated with survival, aortic valve opening area or cardiovascular comorbidities (peripheral, coronary or cerebrovascular disease). Interestingly, long telomeres were significantly correlated to a reduced left ventricular ejection fraction (LVEF).

CONCLUSION:

In elderly patients with severe aortic valve stenosis, leucocyte telomere length did not predict post-procedural survival. The correlation between long telomere length and reduced LVEF in these patients deserves further attention.

PMID:
30861019
DOI:
10.1371/journal.pone.0213250
Free full text

Conflict of interest statement

The authors have declared that no competing interests exist.

Supplemental Content

Full text links

Icon for Public Library of Science
Loading ...
Support Center