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J Neurooncol. 2019 May;143(1):123-127. doi: 10.1007/s11060-019-03144-9. Epub 2019 Mar 11.

The epidemiology of central and extraventricular neurocytoma in the United States between 2006 and 2014.

Author information

1
Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA.
2
Department of Neurosurgery, Cleveland Clinic, Cleveland, OH, USA.
3
Central Brain Tumor Registry of the United States, Hinsdale, IL, USA.
4
Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
5
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
6
Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA. kshettv@ccf.org.
7
Department of Neurosurgery, Cleveland Clinic, Cleveland, OH, USA. kshettv@ccf.org.
8
Skull Base & Cerebrovascular Surgery, Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Ave, CA5-86, Cleveland, OH, 44195, USA. kshettv@ccf.org.

Abstract

INTRODUCTION:

Central neurocytoma (CN) and extraventricular neurocytoma (EVN) are rare intracranial tumors. There is a paucity of studies reporting the population-based incidence of these tumors. We used the Central Brain Tumor Registry of the United States (CBTRUS), which contains the largest aggregation of population-based data on the incidence of primary central nervous system tumors in the United States to describe these tumors.

METHODS:

The CBTRUS database, provided by CDC representing approximately 100% of the US population, was queried using the following search criteria: diagnosis years 2006-2014, ICD-0-3 histology codes (9506/0: central neurocytoma, benign; 9506/1: central neurocytoma, uncertain). Annual age-adjusted incidence rates are presented per 100,000 population. Incidence was estimated by age, gender, race, and ethnicity.

RESULTS:

The combined overall annual incidence rate of CN and EVN was 0.032 [0.030-0.034]. The incidence rates were 0.022 [0.021-0.024] and 0.009 [0.008-0.010] for CN and EVN, respectively. The most frequently documented locations for EVN were frontal lobe and cerebellum, followed by temporal lobe. Peak incidence was found in the 20-34 years range for both CN and EVN. The incidence rate was slightly lower in males compared to females for CN and identical for EVN. The overall incidence rate of CN and EVN combined was lower in Blacks 0.026 [0.021-0.032] and Hispanic Whites 0.020 [0.016-0.025] compared to Non-Hispanic Whites 0.035 [0.033-0.038].

CONCLUSION:

CN and EVN are rare tumors with a peak incidence in the 20-34 years age group. This study represents the largest population-based epidemiological study on CN and EVN in the US.

KEYWORDS:

CBTRUS; Central neurocytoma; Extraventricular neurocytoma; Incidence; SEER

PMID:
30859483
DOI:
10.1007/s11060-019-03144-9

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