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JACC Basic Transl Sci. 2019 Feb 25;4(1):1-14. doi: 10.1016/j.jacbts.2018.10.008. eCollection 2019 Feb.

Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis.

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National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Department of Dermatology, University of Michigan, Ann Arbor, Michigan.
Department of Medicine, Division of Cardiology, New York University School of Medicine, New York, New York.
Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Department of Dermatology, Perelman School of Medicine, Philadelphia, Pennsylvania.
Department of Biostatics, Epidemiology, and Informatics, Perelman School of Medicine, Philadelphia, Pennsylvania.


Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte-platelet interaction may play a crucial target for clinical intervention.


CCTA, coronary computed tomography angiography; CVD, cardiovascular disease; FDR, false discovery rate; HAoEC, human aortic endothelial cell; LDG, low-density granulocyte; MI, myocardial infarction; NCB, noncalcified coronary plaque burden; NDG, normal-density granulocyte; NET, neutrophil extracellular trap; PASI, psoriasis area severity index; SLE, systemic lupus erythematosus; TB, total coronary plaque burden; cardiovascular disease; low-density granulocytes; neutrophils; platelets; psoriasis

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