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Front Biosci (Landmark Ed). 2019 Mar 1;24:1097-1157.

Nano-engineered flavonoids for cancer protection.

Author information

1
Department of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Bhopal, India.
2
School of Pharmacy and Technology Management, Narsee Moonjee Institute of Management Studies, Shirpur, India.
3
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi.
4
Division of Reproductive Biology, Maternal and Child Health, Indian Council of Medical Research, New Delhi, India.
5
Centre for Advanced Studies in Zoology, School of Life Sciences, University of Rajasthan, Jaipur, India.
6
Department of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Bhopal, India, pkm_8bh@yahoo.co.uk.

Abstract

Diet and environment are two critical regulators that influence an individual's epigenetic profile. Besides the anterograde signaling, mitochondria act as a key regulator of epigenetic alterations in cancer either by controlling the concentration of the cofactors, activity of vital enzymes or by affecting the transcription of NF-kappaB and associated signaling molecules. As epigenetic modifications are the major drivers of aberrant gene expression, designing novel nutri-epigenomic strategies to modulate reversible epigenetic modifications will be important for effective cancer protection. In this regard, nutraceuticals such as flavonoids holds significant promise to modulate the epigenome through a network of interconnected anti-redox mechanisms. However, low solubility, rapid metabolism and poor absorption of flavonoids in gastrointestinal tract hinder their use in clinical settings. Therefore, it is imperative to develop nano-engineered systems which could considerably improve the targeted delivery of these bioactive compounds with better efficacy and pharmacokinetic properties. Concerted efforts in nano-engineering of flavonoids using polymer, lipid and complexation based approaches could provide successful bench-to-bedside translation of flavonoids as broad spectrum anti-cancer agents.

PMID:
30844733

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