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Front Biosci (Landmark Ed). 2019 Mar 1;24:1097-1157.

Nano-engineered flavonoids for cancer protection.

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Department of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Bhopal, India.
School of Pharmacy and Technology Management, Narsee Moonjee Institute of Management Studies, Shirpur, India.
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi.
Division of Reproductive Biology, Maternal and Child Health, Indian Council of Medical Research, New Delhi, India.
Centre for Advanced Studies in Zoology, School of Life Sciences, University of Rajasthan, Jaipur, India.
Department of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Bhopal, India,


Diet and environment are two critical regulators that influence an individual's epigenetic profile. Besides the anterograde signaling, mitochondria act as a key regulator of epigenetic alterations in cancer either by controlling the concentration of the cofactors, activity of vital enzymes or by affecting the transcription of NF-kappaB and associated signaling molecules. As epigenetic modifications are the major drivers of aberrant gene expression, designing novel nutri-epigenomic strategies to modulate reversible epigenetic modifications will be important for effective cancer protection. In this regard, nutraceuticals such as flavonoids holds significant promise to modulate the epigenome through a network of interconnected anti-redox mechanisms. However, low solubility, rapid metabolism and poor absorption of flavonoids in gastrointestinal tract hinder their use in clinical settings. Therefore, it is imperative to develop nano-engineered systems which could considerably improve the targeted delivery of these bioactive compounds with better efficacy and pharmacokinetic properties. Concerted efforts in nano-engineering of flavonoids using polymer, lipid and complexation based approaches could provide successful bench-to-bedside translation of flavonoids as broad spectrum anti-cancer agents.


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