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Front Biosci (Landmark Ed). 2019 Mar 1;24:961-970.

The antitumor effect of resveratrol on nasopharyngeal carcinoma cells.

Author information

1
Department of Traditional Chinese Medicine, Chongqing Cancer Institute and Hospital and Cancer Center, Chongqing 400030, P. R. China, xionghuishengcq@163.com.
2
Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400030, P. R. China.
3
Department of Traditional Chinese Medicine, Chongqing Cancer Institute and Hospital and Cancer Center, Chongqing 400030, P. R. China.
4
Department of Interventional Medicine, Chinese PLA Navy General Hospital, 6 Fucheng Road, Beijing, People's Republic of China.

Abstract

The anti-tumor effect of resveratrol has been observed in many cancers. Here, we examined the anti-tumor activity of resveratrol in human nasopharyngeal carcinoma (NPC) cells. Resveratrol, in a dose-dependent manner, inhibited proliferation related proteins (Ki67, PCNA), and cell proliferation, and reduced apoptosis related proteins (cleaved caspase-3, cleaved caspase-9) and apoptosis in nasopharyngeal carcinoma cells. Resveratrol treatment inhibited the increased-expression of Survivin in NPC cells, while the overexpressed Survivin counteracted the effect of resveratrol on cell proliferation and apoptosis in NPC cells, thus establishing Resveratrol-induced reduction in increased-survivin in NPC cells as the underlying mechanism. These findings show that resveratrol can be used to modify the cell growth and death in NPC cells.

PMID:
30844723

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