Format

Send to

Choose Destination
Front Biosci (Landmark Ed). 2019 Mar 1;24:859-869.

Higenamine alleviates cerebral ischemia-reperfusion injury in rats.

Author information

1
Department of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Sichuan, 610072, China.
2
Department of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Sichuan, 610072, China, xiaojia07@163.com.
3
Department of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Sichuan, 610072, China.
4
Hyperbaric oxygen therapy center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Sichuan, 610072, China.

Abstract

Cerebral ischemia reperfusion (I/R) injury is associated with a high incidence of neurological morbidity and mortality worldwide. Higenamine has anti-inflammatory, anti-oxidative and anti-apoptotic capacities and has been successfully used in myocardial and intestinal ischemia reperfusion. We hypothesized that higenamine might serve the same effects in cerebral I/R. In a rat model of cerebral I/R, higenamine improved functional state of nerves, significantly inhibited the I/R-induced increase in the serum level of tumor necrosis factor α (TNF-alpha) and interleukins (ILs) such as IL-1, IL-6 and IL-18, and CD14+ cells, while decreasing the axonal nerve degeneration. Together, the data demonstrate that higenamine has therapeutic effect in cerebral I/R injury.

PMID:
30844718

Supplemental Content

Full text links

Icon for Frontiers in Bioscience
Loading ...
Support Center