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Front Biosci (Landmark Ed). 2019 Mar 1;24:849-858.

Baicalein exerts a protective role in pneumonia caused by Streptococcus pneumoniae.

Author information

1
Henan Key Laboratory of Immunology and Targeted Therapy, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang city, Henan Province, China.
2
No. 371 Center Hospital of PLA, Xinxiang City, Henan Province, China.
3
Henan Key Laboratory of Immunology and Targeted Therapy, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang city, Henan Province, China, xxmuhqs@163.com.

Abstract

Streptococcus pneumoniae is the most common pathogenic bacterium of pneumonia and can cause death. Here, we examined the impact of Baicalein on mouse mortality caused by Streptococcus pneumoniae infection. Baicalein protected mice from Streptococcus pneumoniae-induced deaths. Baicalein reduced alveolocapillary membrane permeability, lung infiltration of inflammatory cells, inflammatory cytokine production and pulmonary cell apoptosis. These evidences show that Baicalein is useful in the therapy of a severe form of pneumonia that can cause deaths.

PMID:
30844717

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