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Front Biosci (Landmark Ed). 2019 Mar 1;24:819-832.

CircRNA_104916 regulates migration, apoptosis and epithelial-mesenchymal transition in colon cancer cells.

Author information

1
Department of Anorectal Surgery, Xinyang Central Hospital, Henan Province, 464000, People\'s Republic of ChinaNo.1 Siyi Road, Xinyang city, Henan province, China.
2
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, People\'s Republic of ChinaNo.57 Changping Road, Shantou city, Guangdong province, China.
3
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, People's Republic of ChinaNo.57 Changping Road, Shantou city, Guangdong province, China, 13809290171@163.com.

Abstract

Circular RNAs (circRNAs) are a class of noncoding RNAs that are differentially expressed in tissues with a great potential in regulating the tumorigenesis and metastasis. The COX proportional hazard model predicts that among these, the relative expression of circRNA_104916 and lymphatic metastatic status independently predict the prognosis of patients with cancer. In the present study, we show that circRNA_104916 is downregulated in colorectal cancers as compared to the adjacent normal tissues. The expression of circRNA_104916 is negatively correlated with the tumor size, T stage and lymphatic metastasis. Patients with higher relative circRNA_104916 expression have a better post-operative disease-free survival as compared with those with lower relative expression. Forced expression of circRNA_104916 induces cell apoptosis and G2/M phase arrest by activating apoptosis pathway and cyclin proteins, thereby inhibiting proliferation of colon cancer cell lines, including LoVo and Caco-2. Additionally, overexpression of circRNA_104916 significantly suppresses migration and invasion of tumor cells by inhibiting the epithelial-mesenchymal transition. In conclusion, this study reveals that circRNA_104916 is a potential biomarker and therapeutic target for colorectal cancers.

PMID:
30844715

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