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Front Biosci (Landmark Ed). 2019 Mar 1;24:765-776.

Recent advances in the regulation of testicular germ cell tumors by microRNAs.

Author information

1
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
2
Changsha Reproductive Medicine Hospital, Hunan, Changsha, 410205, China.
3
Reproductive Medicine Center of People's Hospital of Zhengzhou University, Zhengzhou 450003, China.
4
Reproduction Medical Center, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China.
5
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China, chensuren@ioz.ac.cn.

Abstract

Testicular germ cell tumors (TGCTs) are generally rare but represent the most common solid tumors in young men. They are classified broadly into seminoma, which resemble primordial germ cells (PGCs), and non-seminoma, which are either undifferentiated (embryonic carcinoma) or differentiated (teratoma, yolk sac tumor, choriocarcinomas) patterning. A widespread role for microRNAs (miRNAs), in diverse molecular processes driving initiation and progression of various types of TGCTs has been recently studied. We discuss the involvement of different miRNAs in the development and progression of different types of TGCTs. Moreover, we highlight the aberrant expression of miRNAs in TGCTs and several targets, which may define miRNAs as oncomiRs or tumor suppressors. A better understanding of miRNA biology may ultimately yield further insight into the molecular mechanisms of tumorigenesis and new therapeutic strategies against TGCTs.

PMID:
30844711

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