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Front Biosci (Landmark Ed). 2019 Mar 1;24:712-722.

Life history tradeoffs in humans: increased life expectancy with sperm count reduction.

Author information

1
Shenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong Pr. 518100, China, ruian79@yahoo.com.
2
Department of Oncology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong Pr. 518100, China.
3
Medical College, Xi'an Peihua University, Xi'an, Shaanxi Pr 710125, China.
4
Department of Health Statistics, The Fourth Military Medical University, Xi\'an, Shaanxi Pr 710032, China.

Abstract

Although not without controversy, as a general trend, the human sperm count is declining world-wide. One major reason for such a decline is an increase in the human life-span.  According to the life history tradeoff theory, fecundity is inversely related to the lifespan; the longer the lifespan, the lower the fecundity. This is essential to the maintainance of diversity and balance of different species. Such a corrleation validated by experimental data that show that the extension of life in Caenorhabditis elegans, Drosophila and Rodents is  associated with reduction in fecundity. The demographic data from a public data source, shows that the total fertility rate is positively correlated with the infant death rate, it is inversely correlated with the life expectancy. We postulate that the fall in spermatogenesis might be regulated by the neuroendocrine system that underlie human longevity.

PMID:
30844707

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