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Front Biosci (Landmark Ed). 2019 Mar 1;24:700-711.

Speckle-interferometry and speckle-correlometry of GB-speckles.

Author information

1
Federal Research Center for Virology and Microbiology, Branch in Saratov, Saratov, 410028, Russia.
2
Federal Research Center for Virology and Microbiology, Branch in Saratov, Saratov, 410028, Russia, prof.sergey.ulyanov@outlook.com.

Abstract

A new method of coding of genetic information using laser speckles has been developed. Specific technique of transforming the nucleotide of gene into a speckle pattern (gene-based speckles or GB-speckles) is suggested. Reference speckle patterns of omp1 gene of typical wild strains of Chlamydia trachomatis of genovars D, E, F, G, and J are generated. This is the first report in which perspectives of the proposed technique in the bacterial gene identification and detection of natural genetic mutations in bacteria as a single nucleotide polymorphism (SNP) are demonstrated. The usage of GB-speckles can be viewed as the next step on the way to the era of digital biology.

PMID:
30844706

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