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Carbohydr Polym. 2019 May 1;211:360-369. doi: 10.1016/j.carbpol.2019.01.010. Epub 2019 Jan 4.

Chitosan/fucoidan multilayer coating of gold nanorods as highly efficient near-infrared photothermal agents for cancer therapy.

Author information

1
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Republic of Korea.
2
Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan 48513, Republic of Korea.
3
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Republic of Korea; Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan 48513, Republic of Korea. Electronic address: jungoh@pknu.ac.kr.

Abstract

Photothermal therapy (PTT) using chitosan/fucoidan multilayer coating of gold nanorods (CS/F-GNRs) has emerged as an alternative strategy for cancer therapy. In this study, biocompatible CS/F-GNRs were synthesized as a new generation of photothermal therapeutic agents for in vivo cancer treatments owing to their good biocompatibility, photostability, and strong absorption in the near-infrared (NIR) region. The CS/F-GNRs showed a good size distribution (51.87 ± 3.03 nm), and the temperature variation of the CS/F-GNRs increased by 54.4 °C after laser irradiation (1.0 W/cm2) for 5 min. The in vitro photothermal efficiency of CS/F-GNRs indicated that significantly more cancer cells were killed under laser irradiation at 1.0 W/cm2 for 5 min. On the 20th day of treatment, the MDA-MB-231 tumor cells in mice treated with CS/F-GNRs under laser irradiation had almost completely disappeared. Therefore, the biocompatible CS/F-GNRs have shown great promise as safe and highly efficient near-infrared photothermal agents for future cancer therapy.

KEYWORDS:

Chitosan; Fucoidan; Gold nanorods; Multilayer; Photothermal therapy

PMID:
30824100
DOI:
10.1016/j.carbpol.2019.01.010
[Indexed for MEDLINE]

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