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Mycopathologia. 2019 Feb 25. doi: 10.1007/s11046-019-00325-y. [Epub ahead of print]

In Vitro Susceptibility of Berberine Combined with Antifungal Agents Against the Yeast Form of Talaromyces marneffei.

Author information

1
Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, P. R. China.
2
HIV/AIDS Clinical Treatment Center of Guangxi, The Fourth People's Hospital of Nanning, Nanning, 530023, People's Republic of China.
3
School of Biosciences, The University of Melbourne, Parkville, VIC, Australia.
4
Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Nanning, 530021, People's Republic of China.
5
Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, P. R. China. caocunwei@yeah.net.
6
School of Preclinical Medicine of Guangxi Medical University, No. 22, Shuang Yong Road, Nanning, 530021, People's Republic of China. liangg9507-cn@sina.com.

Abstract

Talaromyces (Penicillium) marneffei can cause fatal disseminated infection in immunocompromised hosts. However, therapeutic strategies for the mycosis are limited. Reports of the other fungi suggest that berberine, a component of traditional herb, inhibitors interact with antifungal agents to improve the treatment outcomes. In the study, we evaluated the in vitro efficacy of berberine in combination with conventional antifungal agents against the pathogenic yeast form of T. marneffei. We demonstrate the synergistic effect of combination of berberine with fluconazole (52.38%), itraconazole (66.67%), voriconazole (71.43%), amphotericin B (71.43%) or caspofungin (52.38%) of T. marneffei strains, respectively. Time-kill curves confirmed the synergistic interaction, and no antagonistic was observed in all of the combinations. In conclusion, berberine could enhance the efficacy of conventional antifungal agents against the yeast form of T. marneffei in vitro. The results indicated berberine might have a potential role in combination therapy for talaromycosis.

KEYWORDS:

Antifungal susceptibility; Berberine; Combined therapy; Talaromyces marneffei

PMID:
30805832
DOI:
10.1007/s11046-019-00325-y

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