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Kidney Int. 2019 Mar;95(3):489-491. doi: 10.1016/j.kint.2018.12.007.

DAMPening sterile inflammation of the kidney.

Author information

1
Institute of Experimental Immunology, University Clinic of Bonn, Rheinische Friedrich Wilhelm University, Bonn, Germany.
2
Institute of Experimental Immunology, University Clinic of Bonn, Rheinische Friedrich Wilhelm University, Bonn, Germany. Electronic address: ckurts@uni-bonn.de.

Abstract

Renal ischemia reperfusion injury (IRI) is a serious cause of acute kidney injury (AKI). Danger-associated-molecular pattern molecules (DAMPs) are thought to promote IRI by initiating immune cell infiltration and driving disease progression, but the underlying pathophysiological mechanisms are mainly unclear. Poluzzi et al. demonstrate that soluble biglycan is a bimodal DAMP that both recruits proinflammatory macrophages and initiates resolution of inflammation and tissue remodeling in IRI, identifying a potential therapeutic target.

KEYWORDS:

ischemia reperfusion; macrophages

PMID:
30784655
DOI:
10.1016/j.kint.2018.12.007

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