Format

Send to

Choose Destination
Rev Med Inst Mex Seguro Soc. 2019 Jan 28;56(5):456-461.

Nontuberculous mycobacteria in cervical lymphadenopathies of HIV positive and HIV-negative adults

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Secretaría de Salud, Hospital General de México “Dr. Eduardo Liceaga”, Unidad de Neumología y Cirugía de Tórax. Ciudad de México, México

Abstract

in English, Spanish

Background:

Tuberculosis is a global public health problem, especially in emerging countries. Mycobacterium tuberculosis is the main cause of cervical lymphadenopathy; nontuberculous mycobacteria are relatively common in children and rare in adults.

Objective:

To identify and establish the frequency of infectious etiology by nontuberculous mycobacteria in Mexican adult patients with cervical lymphadenopathy.

Methods:

The study included 85 patients over 18 years with cervical lymphadenopathy; 45 were HIV-positive, 40 were HIV-negative; they had no history of tuberculosis treatment and were selected from a third-level hospital. It was carried out a biopsy of the lymph node for the histopathological study, a search for acid-fast bacilli, a tube culture to indicate growth of Mycobacterium BACTEC (MGIT-960) and identification of mycobacterial strain by PCR-RFLP (restriction fragment length polymorfism) of hsp65.

Results:

In 42 HIV-positive patients (93%), strains corresponded to Mycobacterium tuberculosis complex, two (4.4%) to M. intracellulare and one (2.2%) to M. gordonae. Among HIV-negative patients, 39 of strains (97.5%) corresponded to patients with M. tuberculosis complex and one strain (2.5%) to M. fortuitum.

Conclusion:

The presence of nontuberculous mycobacteria was found in 4.7% of all cases. Despite this low frequency, it must be taken into account as a possible cause of lymphadenopathy, since its prompt identification enables introducing specific treatment.

KEYWORDS:

Tuberculosis, Lymph Node; Mycobacterium tuberculosis; Nontuberculous Mycobacteria; Cervical Lymphadenopathy

PMID:
30777413
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center