Format

Send to

Choose Destination
Curr Biol. 2019 Mar 4;29(5):726-736.e4. doi: 10.1016/j.cub.2019.01.028. Epub 2019 Feb 14.

Spatial Attention Deficits Are Causally Linked to an Area in Macaque Temporal Cortex.

Author information

1
Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD 20892, USA. Electronic address: bogadhi.amar@gmail.com.
2
Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD 20892, USA.
3
Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA; Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Eye Institute, NIH, Bethesda, MD 20892, USA.
4
Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD 20892, USA. Electronic address: richard.krauzlis@nih.gov.

Abstract

Spatial neglect is a common clinical syndrome involving disruption of the brain's attention-related circuitry, including the dorsocaudal temporal cortex. In macaques, the attention deficits associated with neglect can be readily modeled, but the absence of evidence for temporal cortex involvement has suggested a fundamental difference from humans. To map the neurological expression of neglect-like attention deficits in macaques, we measured attention-related fMRI activity across the cerebral cortex during experimental induction of neglect through reversible inactivation of the superior colliculus and frontal eye fields. During inactivation, monkeys exhibited hallmark attentional deficits of neglect in tasks using either motion or non-motion stimuli. The behavioral deficits were accompanied by marked reductions in fMRI attentional modulation that were strongest in a small region on the floor of the superior temporal sulcus; smaller reductions were also found in frontal eye fields and dorsal parietal cortex. Notably, direct inactivation of the mid-superior temporal sulcus (STS) cortical region identified by fMRI caused similar neglect-like spatial attention deficits. These results identify a putative macaque homolog to temporal cortex structures known to play a central role in human neglect.

KEYWORDS:

fMRI; frontal eye fields; macaque; reversible inactivation; selective attention; spatial neglect; superior colliculus; temporal cortex

PMID:
30773369
PMCID:
PMC6401289
[Available on 2020-03-04]
DOI:
10.1016/j.cub.2019.01.028

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center