Immunogenicity and side-effects of the inactivated hepatitis A vaccine in periodic fever, aphthous stomatitis, pharyngitis, and adenitis patients

Pediatr Int. 2019 Jan;61(1):104-106. doi: 10.1111/ped.13719.

Abstract

The aim of this study was to compare the immunogenicity and side-effects of hepatitis A virus (HAV) vaccination between periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) patients and healthy controls who have not been previously exposed to HAV. A prospective observational study was carried out of 28 PFAPA patients and 76 controls who received two doses of the vaccine. Immunogenicity was expressed as seroconversion and seroprotection rates; mean HAV-immunoglobulin G concentration was measured at 0, 1, 7 and 18 months. Side-effects were defined as incidence of adverse events and the effect of vaccination on PFAPA symptoms. All participants were seronegative and seroconverted at 1 month. One month after primary vaccination, 92.9% of PFAPA patients and 77.6% of the controls attained seroprotection, while the rates increased to 100% and 96.1%, respectively, 1 month after the second dose. Seroprotection rates remained adequate 1 year after completion of vaccination. In conclusion, two doses of the inactivated HAV vaccine are well-tolerated and effective in children with PFAPA.

Keywords: PFAPA; autoinflammatory disorder; hepatitis A vaccine; immunization.

Publication types

  • Observational Study

MeSH terms

  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Hepatitis A Vaccines / adverse effects*
  • Hepatitis A Vaccines / immunology
  • Hereditary Autoinflammatory Diseases / immunology*
  • Humans
  • Immunity, Humoral / immunology
  • Immunoglobulin G / blood
  • Male
  • Prospective Studies

Substances

  • Hepatitis A Vaccines
  • Immunoglobulin G